Cardiac Response to Local Cooling in Man

Effects of local cooling on monosynaptic reflexes in man.

Thermal, cardiac and adrenergic responses to repeated local cooling.

The aim of this study was to ascertain whether repeated local cooling induces the same or different adaptational responses as repeated whole body cooling. Repeated cooling of the legs (immersion into 12 degrees C water up to the knees for 30 min, 20 times during 4 weeks = local cold adaptation - LCA) attenuated the initial increase in heart rate and blood pressure currently observed in control ...

Local cerebral blood volume response to carbon dioxide in man.

We used an emission tomographic brain scanner to investigate the relationship between local cerebral blood volume (LCBV) and arterial blood carbon dioxide tension (PaCO2) in normal awake man. Measurements were made separately in three dimensions in various regions of grey and white matter, and the resting LCBV as well as the difference in sensitivity among these regions were compared. Over the ...

Local ascorbate administration inhibits the adrenergic vasoconstrictor response to local cooling in the human skin.

Local cooling (LC) of nonglabrous skin causes vasoconstriction via the adrenergic and removal of nitric oxide (NO) systems. Since cooling increases reactive oxygen species in smooth muscle cells and induces increased sensitivity of alpha-adrenergic receptors, antioxidant supplementation may attenuate the vasoconstrictor response to skin LC via adrenergic and/or NO systems. To test this hypothes...

Inhibition of the local inflammatory response in man by antimetabolites.

anisms are altered in part by the particular disease process and also, at times, by the therapeutic measures used in these disorders. Antimetabolite therapy, for example, can inhibit both primary and secondary antibody responses, impair the development of delayed hypersensitivity, and block homograft rejection.2 Page and coworkers,3 in a study of the effects of 6-mercaptopurine ( 6-MP) on infla...